This site provides information on hereditary cancer predisposition genes in the Spanish population. Two types of data are submitted by the Spanish genetic diagnostics laboratories: variant classifications and datasets of individual's variants (VCF files); the latter is used to compute population frequencies for each clinical suspicion, sex and laboratory. Additionally, consensus variant interpretations can be submitted from expert groups. Current database version stores ~1.2 million variants found across 4576 individuals in 241 genes. Overall, 22273 unique variants and 17351 classifications were provided by Spanish laboratories and expert groups. 11261 out of the 22273 unique variants were classified by at least one laboratory.

SpadaHC is addressed to research academics, clinical geneticists, genetic counselors and oncologists interested in germline variant interpretation. SpadaHC contains open data, available to any user, and restricted data, available to registered users from Spanish laboratories.

Each new dataset, either of individual's variants or variant classifications, produces a new version of the database:

Variant population frequencies in SpadaHC are calculated from the datasets of individuals (VCF files) submitted by the participating laboratories. The datasets are listed below:

Spanish laboratories and expert groups can submit datasets of variant classifications which are listed below:

This site uses some essential cookies to work. Non-essential cookies, such as analytical cookies or third party cookies, are not used in this site.

Access to this site is subject to the terms and conditions described below.

• Ay publications utilising SpadaHC data must cite the SpadaHC paper, which is available here: Moreno-Cabrera et al.
• Authors who use data from the SpadaHC project must also acknowledge SpadaHC using the following wording: This study/work uses data obtained from SpadaHC. A full list of centers that contributed submitting data to SpadaHC is available here.
• This site is addressed to the scientific and clinical community. Unrestricted-access data can be used by any visitor, while restricted-access data is only available for those users having a registered account.
• The data displayed on this site has been generated with cautiousness and we carry out quality checks to this end. However, note that data may be subjected to NGS processing artifacts. Also, the contents are subject to change without notice.
• Users must employ the data on their own responsibility. Users without a registered account agree to not attempt to re-identify individuals or compromise the privacy of any data individuals in any way. Users with a registered account agree to identify individuals only in the very restricted circumstances described in the agreements signed by their laboratory before participating in this project.